Utilising polymorphisms to achieve allele-specific genome editing in zebrafish
نویسندگان
چکیده
منابع مشابه
Utilising polymorphisms to achieve allele-specific genome editing in zebrafish
The advent of genome editing has significantly altered genetic research, including research using the zebrafish model. To better understand the selectivity of the commonly used CRISPR/Cas9 system, we investigated single base pair mismatches in target sites and examined how they affect genome editing in the zebrafish model. Using two different zebrafish strains that have been deep sequenced, CRI...
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ژورنال
عنوان ژورنال: Biology Open
سال: 2016
ISSN: 2046-6390
DOI: 10.1242/bio.020974